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64. Koch K, Weldle N, Baier S, Büchter C, Wätjen W (2020). Hibiscus sabdariffa L. extract prolongs lifespan and protects against amyloid-β toxicity in Caenorhabditis elegans: Involvement of the FoxO and Nrf2 orthologues DAF-16 and SKN-1. Eur J Nutr, 59:137-150.   

63. Flade J, Beschow H, Wensch-Dorendorf M, Plescher A, Wätjen W (2019). Occurrence of nine pyrrolizidine alkaloids in Senecio vulgaris L. depending on developmental stage and season. Plants, 8:54.   

62. Koch K, Schulz G, Döring W, Büchter C, Havermann S, Mutiso PC, Passreiter C, Wätjen W (2019). Abyssinone V, a prenylated flavonoid isolated from the stem bark of Erythrina melanacantha increases oxidative stress and decreases stress resistance in Caenorhabditis elegans. J Pharm Pharmacol, 71:1007-1016.   

61. Saier C, Gommlich I, Hiemann V, Baier S, Koch K, Horn G, Kowalewsky T, Bartelt J, Seemann M, Wätjen W (2018). Agrimonia procera Wallr. extract increases stress resistance and prolongs life span in Caenorhabditis elegans via transcription factor DAF-16 (FoxO orthologue). Antioxidants, 7:192.   

60. Saier C, Büchter C, Koch K, Wätjen W (2018). Polygonum multiflorumextract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7:60.   

59. Hamed ANE, Schmitz R, Bergermann A, Totzke F, Kubbutat M, Müller WEG, Youssef DTA, Bishr MM, Kamel MS, Edrada-Ebel R, Wätjen W, Proksch P (2018). Bioactive pyrrole alkaloids isolated from the Red Sea: Marine sponge Stylissa carteri. Z Naturforsch C, 73:199-210.   

58. Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017). The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4’-hydroxystilbene and trans-2,4’,5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabdtis elegans. J Pharm Pharmacol, 69:73-81.   

57. Wätjen W, Ebada SS, Bergermann A, Chovolou Y, Totzke F, Kubbutat MHG, Lin W, Proksch P (2017). Cytotoxic effects of the anthraquinone derivatives 1’-deoxyrhodoptilometrin and (S)-(−)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp. Arch Toxicol, 91:1485-1495.   

56. Faust D, Nikolova T, Wätjen W, Kaina B, Dietrich C (2017). The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation. Arch Toxicol, 91:967-982.   

55. Barenys M, Gassmann K, Baksmeier C, Heinz S, Reverte I, Schmuck M, Temme T, Bendt F, Zschauer T-C, Rockel TD, Unfried K, Wätjen W, Sundaram SM, Heuer H, Colomina MT, Fritsche E (2017). Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro. Arch Toxicol, 91:827-837.   

54. Havermann S, Humpf H-U, Wätjen W (2016). Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia, 113:123-127.   

53. Havermann S, Chovolou Y, Humpf H-U, Wätjen W (2016). Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein. Pharm Biol, 54:1491-1502.   

52. Büchter C, Havermann S, Koch K, Wätjen W (2016). Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr, 55:257-265.   

51. Büchter C, Ackermann D, Honnen S, Arnold N, Havermann S, Koch K, Wätjen W (2015). Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food Funct, 6:3383-3392.   

50. Passreiter CM, Suckow-Schnitker A-K, Kulawik A, Addae-Kyereme J, Wright CW, Wätjen W (2015). Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death. Phytochemistry, 117:237-244.   

49. Büchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015). TSG (2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese herb Polygonum multiflorum increases life span and stress resistance of Caenorhabditis elegans. Oxid Med Cell Longev, 2015:124357.   

48. Koch K, Büchter C, Havermann S, Wätjen W (2015). The lignan pinoresinol induces nuclear translocation of DAF-16 in Caenorhabditis elegans but has no effect on life span. Phytother Res, 29:894-901.   

47. Wätjen W, Debbab A, Hohlfeld A, Chovolou Y, Proksch P (2014). The mycotoxin beauvericin induces apoptotic cell death in H4IIE hepatoma cells accompanied by an inhibition of NF-κB-activity and modulation of MAP-kinases. Toxicol Lett, 231:9-16.   

46. Havermann S, Chovolou Y, Humpf H-U, Wätjen W (2014). Caffeic acid phenethylester increases stress resistance and enhances lifespan in Caenorhabditis elegans by modulation of the insulin-like DAF-16 signalling pathway. PLoS ONE, 9:e100256.   

45. Koch K, Havermann S, Büchter C, Wätjen W (2014). Caenorhabditis elegans as model system in pharmacology and toxicology: Effects of flavonoids on redox-sensitive signalling pathways and ageing. ScientificWorldJournal, 2014:920398.   

44. Funk F, Krüger K, Henninger C, Wätjen W, Proksch P, Thomale J, Fritz G (2014). Spongean alkaloids protect rat kidney cells against cisplatin-induced cytotoxicity. Anticancer Drugs, 25:917-929.   

43. Limper C, Wang Y, Ruhl S, Wang Z, Lou Y, Totzke F, Kubbutat MHG, Chovolou Y, Proksch P, Wätjen W (2013). Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J Pharm Pharmacol, 65:1393-1408.   

42. Büchter C, Ackermann D, Havermann S, Honnen S, Chovolou Y, Fritz G, Kampkötter A, Wätjen W (2013). Myricetin-mediated lifespan extension in Caenorhabditis elegans is modulated by DAF-16. Int J Mol Sci, 14:11895-11914.   

41. Hamed ANES, Wätjen W, Schmitz R, Chovolou Y, Edrada-Ebel R, Youssef DTA, Kamel MS, Proksch P (2013). A new bioactive sesquiterpenoid quinone from the Mediterranean sea marine sponge Dysidea avara. Nat Prod Commun, 8:289-292.   

40. Havermann S, Rohrig R, Chovolou Y, Humpf H-U, Wätjen W (2013). Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans: Activation of the Nrf2 signaling pathway and prolongation of lifespan. J Agric Food Chem, 61:2158-2164.   

39. Huber W, Bröhler P, Wätjen W, Frank W, Spingler B, Kunz PC (2012). Cytotoxicity of ruthenium(II) piano-stool complexes with imidazole-based PN ligands. J Organomet Chem, 717:187-194.   

38. Hoffmann M, Honnen S, Mayatepek E, Wätjen W, Koopman WJH, Bossinger O, Distelmaier F (2012). MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans. Exp Gerontol, 47:270-275.   

37. Ackermann D, Büchter C, Chovolou Y, Proksch P, Wätjen W (2012). Uptake of methylated myricetin derivatives in cell culture and C. elegans. Toxicol Lett, 211(Suppl.):S210-S211.   

36. Wetzel C, Kunz PC, Kassack MU, Hamacher A, Böhler P, Wätjen W, Ott I, Rubbiani R, Spingler B (2011). Gold(I) complexes of water-soluble diphos-type ligands: Synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition. Dalton Trans, 40:9212-9220.   

35. Noffke AL, Bongartz M, Wätjen W, Böhler P, Spingler B, Kunz PC (2011). Synthesis, X-ray crystal structure and cytotoxicity of a new tetranuclear ruthenium arene complex. J Organomet Chem, 696:1096–1101.   

34. Chovolou Y, Ebada SS, Wätjen W, Proksch P (2011). Identification of angular naphtopyrones from the Philippine echinoderm Comanthusspecies as inhibitors of the NF-κB signaling pathway. Eur J Pharmacol, 657:26-34.   

33. Brückmann NE, Wahl M, Reiß GJ, Kohns M, Wätjen W, Kunz PC (2011). Polymer conjugates of photoinducible CO-releasing molecules. Eur J Inorg Chem, 29:4571-4577.   

32. Lüpertz R, Wätjen W, Kahl R, Chovolou Y (2010). Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells. Toxicology, 271:115-121.   

31. Shi C, Xu MJ, Bayer M, Deng ZW, Wätjen W, Proksch P, Lin WH (2010). Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa. Phytochemistry, 71:435-442.   

30. Wätjen W, Putz, A, Chovolou Y, Kampkötter A, Totzke F, Kubbutat MHG, Proksch P, Konuklugil B (2009). Hexa-, hepta- and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF-κB signalling in H4IIE cells. J Pharm Pharmacol, 61:919-924.   

29. Wätjen W, Debbab A, Hohlfeld A, Chovolou Y, Kampkötter A, Edrada RA, Ebel R, Hakiki A, Mosaddak M, Totzke F, Kubbutat MHG, Proksch P (2009). Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res, 53:431-440.   

28. Kampkötter A, Chovolou Y, Kulawik A, Röhrdanz E, Weber N, Proksch P, Wätjen W (2008). Isoflavone daidzein possesses no antioxidant activities in cell-free assays but induces the antioxidant enzyme catalase. Nutr Res, 28:620-628.   

27. Lüpertz R, Chovolou Y, Unfried K, Kampkötter A, Wätjen W, Kahl R (2008). The forkhead transcription factor FOXO4 sensitizes cancer cells to doxorubicin-mediated cytotoxicity. Carcinogenesis, 29:2045-2052.   

26. Wätjen W, Suckow-Schnitker AK, Rohrig R, Kulawik A, Addae-Kyereme J, Wright CW, Passreiter CM (2008). Prenylated flavonoid derivatives from the bark of Erythrina addisoniae. J Nat Prod, 71:735-738.   

25. Kampkötter A, Timpel C, Zurawski R, Ruhl S, Chovolou Y, Proksch P, Wätjen W (2008). Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp Biochem Physiol B Biochem Mol Biol, 149:314-323.   

24. Lüpertz R, Chovolou Y, Kampkötter A, Wätjen W, Kahl R (2008). Catalase overexpression impairs TNF-α induced NF-κB activation and sensitizes MCF-7 cells against TNF-α. J Cell Biochem, 103:1497-1511.   

23. Kampkötter A, Wiegand C, Timpel C, Röhrdanz E, Chovolou Y, Kahl R, Wätjen W (2008). Increased expression of catalase in human hepatoma cells by the soy isoflavone, daidzein. Basic Clin Pharmacol Toxicol, 102:437-442.   

22. Wätjen W, Kulawik A, Suckow-Schnitker AK, Chovolou Y, Rohrig R, Ruhl R, Kampkötter A, Addae-Kyereme J, Wright CW, Passreiter CM (2007). Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation. Toxicology, 242:71-79.   

21. Kampkötter A, Nkwonkam CG, Zurawski RF, Timpel C, Chovolou Y, Wätjen W, Kahl R (2007). Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans. Arch Toxicol, 81:849-858.   

20. Wätjen W, Weber N, Lou Y-j, Wang Z-q, Chovolou Y, Kampkötter A, Kahl R, Proksch P (2007). Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells. Food Chem Toxicol, 45:119-124.   

19. Kampkötter A, Pielarski T, Rohrig R, Timpel C, Chovolou Y, Wätjen W, Kahl R (2007). The Ginkgo biloba extract EGb761 reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans. Pharmacol Res, 55:139-147.   

18. Chovolou Y, Wätjen W, Kampkötter A, Kahl R (2007). Downregulation of NF-κB activation in a H4IIE transfectant insensitive to doxorubicin-induced apoptosis. Toxicology, 232:89-98.   

17. Kampkötter A, Nkwonkam CG, Zurawski RF, Timpel C, Chovolou Y, Wätjen W, Kahl R (2007). Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. Toxicology, 234:113-123.   

16. Ashour M, Edrada R, Ebel R, Wray V, Wätjen W, Padmakumar K, Müller WEG, Lin WH, Proksch P (2006). Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia. J Nat Prod, 69:1547-1553.   

15. Michels G, Wätjen W, Weber N., Niering P, Chovolou Y, Kampkötter A, Proksch P, Kahl R (2006). Resveratrol induces apoptotic cell death in rat H4IIE hepatoma cells but necrosis in C6 glioma cells. Toxicology, 225:173-182.   

14. Michels G, Mohamed G, Weber N, Chovolou Y, Kampkötter A, Wätjen W, Proksch P (2006). Effects of methylated derivatives of luteolin isolated from Cyperus alopecuroides in rat H4IIE hepatoma cells. Basic Clin Pharmacol Toxicol, 98:168-172.   

13. Niering P, Michels G, Wätjen W, Ohler S, Steffan B, Chovolou Y, Kampkötter A, Proksch P, Kahl R (2005). Protective and detrimental effects of kaempferol in rat H4IIE cells: Implication of oxidative stress and apoptosis. Toxicol Appl Pharmacol, 209:114-122.   

12. Michels G, Wätjen W, Niering P, Steffan B, Tran-Thi Q-H. Chovolou Y, Kampkötter A, Bast A, Proksch P, Kahl R (2005). Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells. Toxicology, 206:337-348.   

11. Steffan B, Wätjen W, Michels G, Niering P, Wray V, Ebel R, Edrada R, Kahl R, Proksch P (2005). Polyphenols from plants used in traditional Indonesian medicine (Jamu): Uptake and antioxidative effects in rat H4IIE hepatoma cells. J Pharm Pharmacol, 57:233-240.   

10. Wätjen W, Michels G, Steffan B, Niering P, Chovolou Y, Kampkötter A, Tran-Thi Q-H, Proksch P, Kahl R (2005). Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. J Nutr, 135:525-531.   

9. Di Virgilio AL, Iwami K, Wätjen W, Kahl R, Degen GH (2004). Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells. Toxicol Lett, 151:151-162.   

8. Wätjen W, Beyersmann D (2004). Cadmium-induced apoptosis in C6 glioma cells: Influence of oxidative stress. Biometals, 17:65-78.   

7. Michels G, Haenen GR, Wätjen W, Rietjens S, Bast A (2004). The thiol reactivity of the oxidation product of 3,5,7-trihydroxy-4H-chromen-4-one containing flavonoids. Toxicol Lett, 151:105-111.   

6. Chovolou Y, Wätjen W, Kampkötter A, Kahl R (2003). Resistance to Tumor Necrosis Factor-α (TNF-α)-induced apoptosis in rat hepatoma cells expressing TNF-α is linked to low antioxidant enzyme expression. J Biol Chem, 278:29626-29632.   

5. Wätjen W, Biagioli M, Cox M, Beyersmann D (2002). Cadmium induces apoptosis in C6 glioma cells mediated by caspase 9-activation. Biometals, 15:15-25.   

4. Wätjen W, Haase H, Biagioli M, Beyersmann D (2002). Induction of apoptosis in mammalian cells by cadmium and zinc. Environ Health Perspect, 110:865-867.   

3. Biagioli M, Wätjen W, Beyersmann D, Zoncu R, Cappellini C, Ragghianti M, Cremisi F, Bucci S (2001). Cadmium induced apoptosis in murine fibroblasts is suppressed by Bcl-2. Arch Toxicol, 75:313-320.   

2. Haase H, Wätjen W, Beyersmann D (2001). Zinc induces apoptosis that can be suppressed by lanthanum in C6 rat glioma cells. Biol Chem, 382:1227-1234.   

1. Wätjen W, Benters J, Haase H, Schwede F, Jastorff B, Beyersmann D (2001). Zn2+ and Cd2+ increase the cyclic GMP level in PC12 cells by inhibition of the cyclic nucleotide phosphodiesterase. Toxicology, 157:167-175.   

Review articles

5. Schrögel P, Wätjen W (2019). Insects for food and feed-safety aspects related to mycotoxins and metals. Foods, 8:288.   

4. Wätjen W, Fritsche E. Rolle des Fremdstoffmetabolismus in Pharmakologie und Toxikologie: Teil 2: Phase-II-Reaktionen, Apotheken-Magazin 9, 6-13, 2010

3. Wätjen W, Fritsche E. Rolle des Fremdstoffmetabolismus in Pharmakologie und Toxikologie: Teil 1: Phase-I-Reaktionen, Apotheken-Magazin 5, 8-14, 2009

2. Passreiter C, Wätjen W. Hexenkräuter, Hexenmedizin. Apotheken-Magazin 5, 8-14, 2007

1. Kahl R, Kampkötter A, Wätjen W, Chovolou Y. Antioxidant enzymes and apoptosis. Drug Metabolism Reviews, 36, 747-762, 2004

Books and book chapters