Publikationen
Research articles
64. Koch K, Weldle N, Baier S, Büchter C, Wätjen W (2020). Hibiscus sabdariffa L. extract prolongs lifespan and protects against amyloid-β toxicity in Caenorhabditis elegans: Involvement of the FoxO and Nrf2 orthologues DAF-16 and SKN-1. Eur J Nutr, 59:137-150. https://doi.org/10.1007/s00394-019-01894-w
63. Flade J, Beschow H, Wensch-Dorendorf M, Plescher A, Wätjen W (2019). Occurrence of nine pyrrolizidine alkaloids in Senecio vulgaris L. depending on developmental stage and season. Plants, 8:54. https://doi.org/10.3390/plants8030054
62. Koch K, Schulz G, Döring W, Büchter C, Havermann S, Mutiso PC, Passreiter C, Wätjen W (2019). Abyssinone V, a prenylated flavonoid isolated from the stem bark of Erythrina melanacantha increases oxidative stress and decreases stress resistance in Caenorhabditis elegans. J Pharm Pharmacol, 71:1007-1016. https://doi.org/10.1111/jphp.13074
61. Saier C, Gommlich I, Hiemann V, Baier S, Koch K, Horn G, Kowalewsky T, Bartelt J, Seemann M, Wätjen W (2018). Agrimonia procera Wallr. extract increases stress resistance and prolongs life span in Caenorhabditis elegans via transcription factor DAF-16 (FoxO orthologue). Antioxidants, 7:192. https://doi.org/10.3390/antiox7120192
60. Saier C, Büchter C, Koch K, Wätjen W (2018). Polygonum multiflorumextract exerts antioxidative effects and increases life span and stress resistance in the model organism Caenorhabditis elegans via DAF-16 and SIR-2.1. Plants, 7:60. https://doi.org/10.3390/plants7030060
59. Hamed ANE, Schmitz R, Bergermann A, Totzke F, Kubbutat M, Müller WEG, Youssef DTA, Bishr MM, Kamel MS, Edrada-Ebel R, Wätjen W, Proksch P (2018). Bioactive pyrrole alkaloids isolated from the Red Sea: Marine sponge Stylissa carteri. Z Naturforsch C, 73:199-210. https://doi.org/10.1515/znc-2017-0161
58. Fischer N, Büchter C, Koch K, Albert S, Csuk R, Wätjen W (2017). The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4’-hydroxystilbene and trans-2,4’,5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabdtis elegans. J Pharm Pharmacol, 69:73-81. https://doi.org/10.1111/jphp.12657
57. Wätjen W, Ebada SS, Bergermann A, Chovolou Y, Totzke F, Kubbutat MHG, Lin W, Proksch P (2017). Cytotoxic effects of the anthraquinone derivatives 1’-deoxyrhodoptilometrin and (S)-(−)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp. Arch Toxicol, 91:1485-1495. https://doi.org/10.1007/s00204-016-1787-7
56. Faust D, Nikolova T, Wätjen W, Kaina B, Dietrich C (2017). The Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation. Arch Toxicol, 91:967-982. https://doi.org/10.1007/s00204-016-1672-4
55. Barenys M, Gassmann K, Baksmeier C, Heinz S, Reverte I, Schmuck M, Temme T, Bendt F, Zschauer T-C, Rockel TD, Unfried K, Wätjen W, Sundaram SM, Heuer H, Colomina MT, Fritsche E (2017). Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro. Arch Toxicol, 91:827-837. https://doi.org/10.1007/s00204-016-1709-8
54. Havermann S, Humpf H-U, Wätjen W (2016). Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16. Fitoterapia, 113:123-127. https://doi.org/10.1016/j.fitote.2016.06.018
53. Havermann S, Chovolou Y, Humpf H-U, Wätjen W (2016). Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein. Pharm Biol, 54:1491-1502. https://doi.org/10.3109/13880209.2015.1104703
52. Büchter C, Havermann S, Koch K, Wätjen W (2016). Isoxanthohumol, a constituent of hop (Humulus lupulus L.), increases stress resistance in Caenorhabditis elegans dependent on the transcription factor DAF-16. Eur J Nutr, 55:257-265. https://doi.org/10.1007/s00394-015-0843-z
51. Büchter C, Ackermann D, Honnen S, Arnold N, Havermann S, Koch K, Wätjen W (2015). Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food Funct, 6:3383-3392. https://doi.org/10.1039/C5FO00463B
50. Passreiter CM, Suckow-Schnitker A-K, Kulawik A, Addae-Kyereme J, Wright CW, Wätjen W (2015). Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death. Phytochemistry, 117:237-244. https://doi.org/10.1016/j.phytochem.2015.04.002
49. Büchter C, Zhao L, Havermann S, Honnen S, Fritz G, Proksch P, Wätjen W (2015). TSG (2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese herb Polygonum multiflorum increases life span and stress resistance of Caenorhabditis elegans. Oxid Med Cell Longev, 2015:124357. https://doi.org/10.1155/2015/124357
48. Koch K, Büchter C, Havermann S, Wätjen W (2015). The lignan pinoresinol induces nuclear translocation of DAF-16 in Caenorhabditis elegans but has no effect on life span. Phytother Res, 29:894-901. https://doi.org/10.1002/ptr.5330
47. Wätjen W, Debbab A, Hohlfeld A, Chovolou Y, Proksch P (2014). The mycotoxin beauvericin induces apoptotic cell death in H4IIE hepatoma cells accompanied by an inhibition of NF-κB-activity and modulation of MAP-kinases. Toxicol Lett, 231:9-16. https://doi.org/10.1016/j.toxlet.2014.08.021
46. Havermann S, Chovolou Y, Humpf H-U, Wätjen W (2014). Caffeic acid phenethylester increases stress resistance and enhances lifespan in Caenorhabditis elegans by modulation of the insulin-like DAF-16 signalling pathway. PLoS ONE, 9:e100256. https://doi.org/10.1371/journal.pone.0100256
45. Koch K, Havermann S, Büchter C, Wätjen W (2014). Caenorhabditis elegans as model system in pharmacology and toxicology: Effects of flavonoids on redox-sensitive signalling pathways and ageing. ScientificWorldJournal, 2014:920398. https://doi.org/10.1155/2014/920398
44. Funk F, Krüger K, Henninger C, Wätjen W, Proksch P, Thomale J, Fritz G (2014). Spongean alkaloids protect rat kidney cells against cisplatin-induced cytotoxicity. Anticancer Drugs, 25:917-929. https://doi.org/10.1097/CAD.0000000000000119
43. Limper C, Wang Y, Ruhl S, Wang Z, Lou Y, Totzke F, Kubbutat MHG, Chovolou Y, Proksch P, Wätjen W (2013). Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J Pharm Pharmacol, 65:1393-1408. https://doi.org/10.1111/jphp.12107
42. Büchter C, Ackermann D, Havermann S, Honnen S, Chovolou Y, Fritz G, Kampkötter A, Wätjen W (2013). Myricetin-mediated lifespan extension in Caenorhabditis elegans is modulated by DAF-16. Int J Mol Sci, 14:11895-11914. https://doi.org/10.3390/ijms140611895
41. Hamed ANES, Wätjen W, Schmitz R, Chovolou Y, Edrada-Ebel R, Youssef DTA, Kamel MS, Proksch P (2013). A new bioactive sesquiterpenoid quinone from the Mediterranean sea marine sponge Dysidea avara. Nat Prod Commun, 8:289-292. https://doi.org/10.1177%2F1934578X1300800303
40. Havermann S, Rohrig R, Chovolou Y, Humpf H-U, Wätjen W (2013). Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans: Activation of the Nrf2 signaling pathway and prolongation of lifespan. J Agric Food Chem, 61:2158-2164. https://doi.org/10.1021/jf304553g
39. Huber W, Bröhler P, Wätjen W, Frank W, Spingler B, Kunz PC (2012). Cytotoxicity of ruthenium(II) piano-stool complexes with imidazole-based PN ligands. J Organomet Chem, 717:187-194. https://doi.org/10.1016/j.jorganchem.2012.06.027
38. Hoffmann M, Honnen S, Mayatepek E, Wätjen W, Koopman WJH, Bossinger O, Distelmaier F (2012). MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans. Exp Gerontol, 47:270-275. https://doi.org/10.1016/j.exger.2011.12.011
37. Ackermann D, Büchter C, Chovolou Y, Proksch P, Wätjen W (2012). Uptake of methylated myricetin derivatives in cell culture and C. elegans. Toxicol Lett, 211(Suppl.):S210-S211. https://doi.org/10.1016/j.toxlet.2012.03.754
36. Wetzel C, Kunz PC, Kassack MU, Hamacher A, Böhler P, Wätjen W, Ott I, Rubbiani R, Spingler B (2011). Gold(I) complexes of water-soluble diphos-type ligands: Synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition. Dalton Trans, 40:9212-9220. https://doi.org/10.1039/C1DT10368G
35. Noffke AL, Bongartz M, Wätjen W, Böhler P, Spingler B, Kunz PC (2011). Synthesis, X-ray crystal structure and cytotoxicity of a new tetranuclear ruthenium arene complex. J Organomet Chem, 696:1096–1101. https://doi.org/10.1016/j.jorganchem.2010.10.042
34. Chovolou Y, Ebada SS, Wätjen W, Proksch P (2011). Identification of angular naphtopyrones from the Philippine echinoderm Comanthusspecies as inhibitors of the NF-κB signaling pathway. Eur J Pharmacol, 657:26-34. https://doi.org/10.1016/j.ejphar.2011.01.039
33. Brückmann NE, Wahl M, Reiß GJ, Kohns M, Wätjen W, Kunz PC (2011). Polymer conjugates of photoinducible CO-releasing molecules. Eur J Inorg Chem, 29:4571-4577. https://doi.org/10.1002/ejic.201100545
32. Lüpertz R, Wätjen W, Kahl R, Chovolou Y (2010). Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells. Toxicology, 271:115-121. https://doi.org/10.1016/j.tox.2010.03.012
31. Shi C, Xu MJ, Bayer M, Deng ZW, Wätjen W, Proksch P, Lin WH (2010). Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa. Phytochemistry, 71:435-442. https://doi.org/10.1016/j.phytochem.2009.11.008
30. Wätjen W, Putz, A, Chovolou Y, Kampkötter A, Totzke F, Kubbutat MHG, Proksch P, Konuklugil B (2009). Hexa-, hepta- and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF-κB signalling in H4IIE cells. J Pharm Pharmacol, 61:919-924. https://doi.org/10.1211/jpp.61.07.0011
29. Wätjen W, Debbab A, Hohlfeld A, Chovolou Y, Kampkötter A, Edrada RA, Ebel R, Hakiki A, Mosaddak M, Totzke F, Kubbutat MHG, Proksch P (2009). Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res, 53:431-440. https://doi.org/10.1002/mnfr.200700428
28. Kampkötter A, Chovolou Y, Kulawik A, Röhrdanz E, Weber N, Proksch P, Wätjen W (2008). Isoflavone daidzein possesses no antioxidant activities in cell-free assays but induces the antioxidant enzyme catalase. Nutr Res, 28:620-628. https://doi.org/10.1016/j.nutres.2008.06.002
27. Lüpertz R, Chovolou Y, Unfried K, Kampkötter A, Wätjen W, Kahl R (2008). The forkhead transcription factor FOXO4 sensitizes cancer cells to doxorubicin-mediated cytotoxicity. Carcinogenesis, 29:2045-2052. https://doi.org/10.1093/carcin/bgn184
26. Wätjen W, Suckow-Schnitker AK, Rohrig R, Kulawik A, Addae-Kyereme J, Wright CW, Passreiter CM (2008). Prenylated flavonoid derivatives from the bark of Erythrina addisoniae. J Nat Prod, 71:735-738. https://doi.org/10.1021/np070417j
25. Kampkötter A, Timpel C, Zurawski R, Ruhl S, Chovolou Y, Proksch P, Wätjen W (2008). Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp Biochem Physiol B Biochem Mol Biol, 149:314-323. https://doi.org/10.1016/j.cbpb.2007.10.004
24. Lüpertz R, Chovolou Y, Kampkötter A, Wätjen W, Kahl R (2008). Catalase overexpression impairs TNF-α induced NF-κB activation and sensitizes MCF-7 cells against TNF-α. J Cell Biochem, 103:1497-1511. https://doi.org/10.1002/jcb.21538
23. Kampkötter A, Wiegand C, Timpel C, Röhrdanz E, Chovolou Y, Kahl R, Wätjen W (2008). Increased expression of catalase in human hepatoma cells by the soy isoflavone, daidzein. Basic Clin Pharmacol Toxicol, 102:437-442. https://doi.org/10.1111/j.1742-7843.2007.00173.x
22. Wätjen W, Kulawik A, Suckow-Schnitker AK, Chovolou Y, Rohrig R, Ruhl R, Kampkötter A, Addae-Kyereme J, Wright CW, Passreiter CM (2007). Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation. Toxicology, 242:71-79. https://doi.org/10.1016/j.tox.2007.09.010
21. Kampkötter A, Nkwonkam CG, Zurawski RF, Timpel C, Chovolou Y, Wätjen W, Kahl R (2007). Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans. Arch Toxicol, 81:849-858. https://doi.org/10.1007/s00204-007-0215-4
20. Wätjen W, Weber N, Lou Y-j, Wang Z-q, Chovolou Y, Kampkötter A, Kahl R, Proksch P (2007). Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells. Food Chem Toxicol, 45:119-124. https://doi.org/10.1016/j.fct.2006.08.008
19. Kampkötter A, Pielarski T, Rohrig R, Timpel C, Chovolou Y, Wätjen W, Kahl R (2007). The Ginkgo biloba extract EGb761 reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans. Pharmacol Res, 55:139-147. https://doi.org/10.1016/j.phrs.2006.11.006
18. Chovolou Y, Wätjen W, Kampkötter A, Kahl R (2007). Downregulation of NF-κB activation in a H4IIE transfectant insensitive to doxorubicin-induced apoptosis. Toxicology, 232:89-98. https://doi.org/10.1016/j.tox.2006.12.012
17. Kampkötter A, Nkwonkam CG, Zurawski RF, Timpel C, Chovolou Y, Wätjen W, Kahl R (2007). Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. Toxicology, 234:113-123. https://doi.org/10.1016/j.tox.2007.02.006
16. Ashour M, Edrada R, Ebel R, Wray V, Wätjen W, Padmakumar K, Müller WEG, Lin WH, Proksch P (2006). Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia. J Nat Prod, 69:1547-1553. https://doi.org/10.1021/np060172v
15. Michels G, Wätjen W, Weber N., Niering P, Chovolou Y, Kampkötter A, Proksch P, Kahl R (2006). Resveratrol induces apoptotic cell death in rat H4IIE hepatoma cells but necrosis in C6 glioma cells. Toxicology, 225:173-182. https://doi.org/10.1016/j.tox.2006.05.014
14. Michels G, Mohamed G, Weber N, Chovolou Y, Kampkötter A, Wätjen W, Proksch P (2006). Effects of methylated derivatives of luteolin isolated from Cyperus alopecuroides in rat H4IIE hepatoma cells. Basic Clin Pharmacol Toxicol, 98:168-172. https://doi.org/10.1111/j.1742-7843.2006.pto_300.x
13. Niering P, Michels G, Wätjen W, Ohler S, Steffan B, Chovolou Y, Kampkötter A, Proksch P, Kahl R (2005). Protective and detrimental effects of kaempferol in rat H4IIE cells: Implication of oxidative stress and apoptosis. Toxicol Appl Pharmacol, 209:114-122. https://doi.org/10.1016/j.taap.2005.04.004
12. Michels G, Wätjen W, Niering P, Steffan B, Tran-Thi Q-H. Chovolou Y, Kampkötter A, Bast A, Proksch P, Kahl R (2005). Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells. Toxicology, 206:337-348. https://doi.org/10.1016/j.tox.2004.07.022
11. Steffan B, Wätjen W, Michels G, Niering P, Wray V, Ebel R, Edrada R, Kahl R, Proksch P (2005). Polyphenols from plants used in traditional Indonesian medicine (Jamu): Uptake and antioxidative effects in rat H4IIE hepatoma cells. J Pharm Pharmacol, 57:233-240. https://doi.org/10.1211/0022357055317
10. Wätjen W, Michels G, Steffan B, Niering P, Chovolou Y, Kampkötter A, Tran-Thi Q-H, Proksch P, Kahl R (2005). Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. J Nutr, 135:525-531. https://doi.org/10.1093/jn/135.3.525
9. Di Virgilio AL, Iwami K, Wätjen W, Kahl R, Degen GH (2004). Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells. Toxicol Lett, 151:151-162. https://doi.org/10.1016/j.toxlet.2004.04.005
8. Wätjen W, Beyersmann D (2004). Cadmium-induced apoptosis in C6 glioma cells: Influence of oxidative stress. Biometals, 17:65-78. https://doi.org/10.1023/A:1024405119018
7. Michels G, Haenen GR, Wätjen W, Rietjens S, Bast A (2004). The thiol reactivity of the oxidation product of 3,5,7-trihydroxy-4H-chromen-4-one containing flavonoids. Toxicol Lett, 151:105-111. https://doi.org/10.1016/j.toxlet.2004.01.017
6. Chovolou Y, Wätjen W, Kampkötter A, Kahl R (2003). Resistance to Tumor Necrosis Factor-α (TNF-α)-induced apoptosis in rat hepatoma cells expressing TNF-α is linked to low antioxidant enzyme expression. J Biol Chem, 278:29626-29632. https://doi.org/10.1074/jbc.M208665200
5. Wätjen W, Biagioli M, Cox M, Beyersmann D (2002). Cadmium induces apoptosis in C6 glioma cells mediated by caspase 9-activation. Biometals, 15:15-25. https://doi.org/10.1023/A:1013141926228
4. Wätjen W, Haase H, Biagioli M, Beyersmann D (2002). Induction of apoptosis in mammalian cells by cadmium and zinc. Environ Health Perspect, 110:865-867. https://doi.org/10.1289/ehp.110-1241262
3. Biagioli M, Wätjen W, Beyersmann D, Zoncu R, Cappellini C, Ragghianti M, Cremisi F, Bucci S (2001). Cadmium induced apoptosis in murine fibroblasts is suppressed by Bcl-2. Arch Toxicol, 75:313-320. https://doi.org/10.1007/s002040100236
2. Haase H, Wätjen W, Beyersmann D (2001). Zinc induces apoptosis that can be suppressed by lanthanum in C6 rat glioma cells. Biol Chem, 382:1227-1234. https://doi.org/10.1515/BC.2001.153
1. Wätjen W, Benters J, Haase H, Schwede F, Jastorff B, Beyersmann D (2001). Zn2+ and Cd2+ increase the cyclic GMP level in PC12 cells by inhibition of the cyclic nucleotide phosphodiesterase. Toxicology, 157:167-175. https://doi.org/10.1016/S0300-483X(00)00370-X
Review articles
7. Eisenbrand G, Baum M, Cartus AT, Diel P, Engel K-H, Engeli B, Epe B, Grune T, Guth S, Haller D, Heinz V, Hellwig M, Hengstler JG, Henle T, Humpf H-U, Jäger H, Joost H-G, Kulling S, Lachenmeier DW, Lampen A, Leist M, Mally A, Marko D, Nöthlings U, Röhrdanz E, Roth A, Spranger J, Stadler R, Vieths S, Wätjen W, Steinberg P (2022). Salivary nitrate/nitrite and acetaldehyde in humans: Potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—A hypothesis. Arch Toxicol, 96:1905-1914. https://doi.org/10.1007/s00204-022-03296-0
6. Schümmer T, Stangl GI, Wätjen W (2021). Safety assessment of vitamin D and its photo-isomers in UV-irradiated Baker's yeast. Foods, 10:3142. https://doi.org/10.3390/foods10123142
5. Schrögel P, Wätjen W (2019). Insects for food and feed-safety aspects related to mycotoxins and metals. Foods, 8:288. https://doi.org/10.3390/foods8080288
4. Wätjen W, Fritsche E. Rolle des Fremdstoffmetabolismus in Pharmakologie und Toxikologie: Teil 2: Phase-II-Reaktionen, Apotheken-Magazin 9, 6-13, 2010
3. Wätjen W, Fritsche E. Rolle des Fremdstoffmetabolismus in Pharmakologie und Toxikologie: Teil 1: Phase-I-Reaktionen, Apotheken-Magazin 5, 8-14, 2009
2. Passreiter C, Wätjen W. Hexenkräuter, Hexenmedizin. Apotheken-Magazin 5, 8-14, 2007
1. Kahl R, Kampkötter A, Wätjen W, Chovolou Y. Antioxidant enzymes and apoptosis. Drug Metabolism Reviews, 36, 747-762, 2004